Across TCGA patient cohorts, GPR141 mutation is significantly associated with the RNA expression of many other genes, with 1,583 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR141-associated genes across cancer lineages are RPS6KB2, RNU6-567P, and RNU6-826P. Each is linked with GPR141 in more than 2 cancer types. Because this analysis shows association rather than direction, both GPR141-to-partner and partner-to-GPR141 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR141→partner) and Y-score (partner→GPR141) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPS6KB2 →	+0.477	+3.732	<.001	<.001	3	3
LUAD	RNU6-567P →	+0.133	+3.899	<.001	.008	3	3
BRCA	RNU6-826P →	+0.588	+6.064	<.001	.002	3	3
LUSC	PSMD7P1 →	+0.174	+2.845	.001	.006	3	3
SKCM	STIP1 →	+0.458	+3.738	.001	<.001	3	3
SKCM	FEN1 →	+0.561	+2.508	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,583 associations by consensus.

Exploration

GPR141 survival (RNA) · tumor vs normal (RNA) · all GPR141 data types