Across TCGA patient cohorts, GPR141 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR141-associated genes across cancer lineages are PKC-a_pS657, MEK1, and PCNA. Each is linked with GPR141 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR141-to-partner and partner-to-GPR141 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR141→partner) and Y-score (partner→GPR141) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-a_pS657 →	-0.350	-2.321	.036	.033	3	2
UCEC	MEK1 →	+0.412	+3.459	.009	.005	3	2
UCEC	PCNA →	+0.216	+2.807	.022	.003	3	2
UCEC	Cyclin-B1 →	+0.601	+3.169	.014	.018	3	2
SKCM	B-Raf →	-0.376	-3.321	.031	.009	3	2
LUAD	N-Ras →	+0.104	+2.459	.012	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Exploration

GPR141 survival (RNA) · tumor vs normal (RNA) · all GPR141 data types