GPR139

Across TCGA pan-cancer cohorts, GPR139 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GPR139 data layer compared with 12 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher GPR139 Mutation is associated with better overall survival. In most high-consensus cancer types, elevated GPR139 expression acts as an unfavorable survival marker, although some lineages such as SCLC and SKCM show a favorable association.

SCLC, LIHC, and LGG are the cancer types where GPR139 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	IV	0.959	0.274	.010	12	view →
LIHC	DFS	Median	All	0.049	0.544	<.001	12	view →
LGG	DFS	Median	All	0.077	0.845	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	OS	Median	All	1.000	0.862	.005	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GPR139–SCLC (OS)

Open the SCLC breakdown →