GPR139

Across TCGA patient cohorts, GPR139 mutation is significantly associated with the RNA expression of many other genes, with 3,928 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR139-associated genes across cancer lineages are PSMD2, FANCG, and CCDC47. Each is linked with GPR139 in more than 3 cancer types. Because this analysis shows association rather than direction, both GPR139-to-partner and partner-to-GPR139 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMD2 grouped by GPR139-low versus GPR139-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR139→partner) and Y-score (partner→GPR139) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PSMD2 →	+0.327	+1.950	.005	<.001	3	4
UCEC	FANCG →	+0.696	+3.818	<.001	<.001	3	3
UCEC	CCDC47 →	+0.541	+2.254	.004	.005	3	3
UCEC	WRAP53 →	+0.393	+3.374	.009	.004	3	3
COAD	MIR6870 →	+0.467	+2.893	.006	.008	3	3
SKCM	CUEDC1 →	+0.413	+4.050	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,928 associations by consensus.

PSMD2 by GPR139 expression — SKCM

Explore this box plot interactively →