GPR139

Across TCGA patient cohorts, GPR139 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR139-associated genes across cancer lineages are GAPDH, MEK1, and p38-MAPK_pT180_Y182. Each is linked with GPR139 in more than 2 cancer types. Because this analysis shows association rather than direction, both GPR139-to-partner and partner-to-GPR139 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by GPR139-low versus GPR139-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR139→partner) and Y-score (partner→GPR139) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GAPDH →	+0.488	+1.874	.029	.049	3	3
UCEC	MEK1 →	+0.498	+2.906	<.001	.001	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.561	-1.986	.001	.010	3	2
UCEC	PDCD4 →	-0.648	-2.502	<.001	.002	3	2
UCEC	TFRC →	+0.570	+2.459	.006	.019	3	2
SKCM	JNK2 →	+0.156	+1.597	.046	.040	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

GAPDH by GPR139 expression — SKCM

Explore this box plot interactively →