GPR139

Across TCGA cell cohorts, GPR139 RNA expression is significantly associated with the mutation status of many other genes, with 114 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible GPR139-associated genes across cancer lineages are KIF5A, ARIH1, and TRPC3. Each is linked with GPR139 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR139-to-partner and partner-to-GPR139 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIF5A grouped by GPR139-low versus GPR139-high in CNS.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR139→partner) and Y-score (partner→GPR139) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	KIF5A →	+6.357	+0.036	<.001	<.001	3	2
CNS	ARIH1 →	+4.357	+0.018	.004	<.001	3	2
UPPER_AERODIGESTIVE_TRACT	TRPC3 →	+4.736	+0.076	.009	<.001	3	2
UPPER_AERODIGESTIVE_TRACT	SMARCC2 →	+4.736	+0.076	.009	<.001	3	2
UPPER_AERODIGESTIVE_TRACT	MIDEAS →	+4.736	+0.076	.009	<.001	3	2
UPPER_AERODIGESTIVE_TRACT	ZNF746 →	+4.736	+0.076	.009	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 114 associations by consensus.

KIF5A by GPR139 expression — CNS

Explore this box plot interactively →