GPR139

Across TCGA cell cohorts, GPR139 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GPR139-associated genes across cancer lineages are DMRTB1, ASPN, and TBR1. Each is linked with GPR139 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR139-to-partner and partner-to-GPR139 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DMRTB1 grouped by GPR139-low versus GPR139-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR139→partner) and Y-score (partner→GPR139) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DMRTB1 →	+0.004	+3.887	<.001	.002	3	1
LARGE_INTESTINE	ASPN →	+0.051	+3.648	<.001	.002	3	1
LARGE_INTESTINE	TBR1 →	+0.030	+3.555	.009	.003	3	1
LARGE_INTESTINE	PROP1 →	+0.017	+2.791	.003	.005	3	1
LARGE_INTESTINE	PTTG2 →	+0.072	+3.497	.003	.004	3	1
CNS	GAGE12G →	+0.081	+5.754	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

DMRTB1 by GPR139 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →