GPR137

Across TCGA patient cohorts, GPR137 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR137-associated genes across cancer lineages are MEK1, eIF4E, and MSH6. Each is linked with GPR137 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR137-to-partner and partner-to-GPR137 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by GPR137-low versus GPR137-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR137→partner) and Y-score (partner→GPR137) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.315	+2.584	.037	.010	3	2
UCEC	eIF4E →	+0.172	+2.584	.048	.010	3	1
UCEC	MSH6 →	-0.417	-2.321	.002	.033	3	1
UCEC	p62 Lck ligand →	+0.367	+2.331	.006	.019	3	1
UCEC	p90 RSK_pT359_S363 →	+0.196	+2.179	.019	.034	3	1
UCEC	PDK1_pS241 →	+0.158	+2.321	.025	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

MEK1 by GPR137 expression — UCEC

Explore this box plot interactively →