GPR137

Across TCGA cell cohorts, GPR137 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,355 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GPR137-associated GO terms across cancer lineages are Regulation of cytoplasmic pattern recognition receptor signaling pathway, Positive regulation of intracellular estrogen receptor signaling pathway, and Vacuole organization. Each is linked with GPR137 in more than 13 cancer types. Because this analysis shows association rather than direction, both GPR137-to-partner and partner-to-GPR137 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cytoplasmic pattern recognition receptor signaling pathway grouped by GPR137-low versus GPR137-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR137→partner) and Y-score (partner→GPR137) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Regulation of cytoplasmic pattern recognition receptor signaling pathway →	+0.053	+0.812	<.001	.001	3	14
BONE	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.163	+0.696	.004	<.001	3	14
OESOPHAGUS	Vacuole organization →	+0.060	+1.324	<.001	<.001	3	14
OESOPHAGUS	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.196	+1.202	<.001	.008	3	14
UPPER_AERODIGESTIVE_TRACT	Endosomal transport →	+0.062	+1.122	<.001	<.001	3	14
BONE	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.207	+0.798	.004	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,355 associations by consensus.

Regulation of cytoplasmic pattern recognition receptor signaling pathway by GPR137 expression — KIDNEY

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