GPR137

Across TCGA cell cohorts, GPR137 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GPR137-associated genes across cancer lineages are MAGEB5, TNP1, and GALR1. Each is linked with GPR137 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR137-to-partner and partner-to-GPR137 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB5 grouped by GPR137-low versus GPR137-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR137→partner) and Y-score (partner→GPR137) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
LARGE_INTESTINE	TNP1 →	+0.160	+4.415	<.001	.007	3	1
SKIN	GALR1 →	+1.296	+6.022	<.001	.001	3	1
SKIN	NPAP1 →	+0.006	+5.415	<.001	.004	3	1
SKIN	KRTAP5-5 →	+0.023	+6.022	<.001	.001	3	1
BLOOD_Leukemia	MMP27 →	+0.015	+4.384	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

MAGEB5 by GPR137 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →