GPR135

Across TCGA pan-cancer cohorts, GPR135 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated GPR135 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in thyroid carcinoma (THCA), where higher GPR135 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GPR135 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

THCA, KIRC, and UCEC are the cancer types where GPR135 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Median	All	0.032	0.950	<.001	48	view →
KIRC	OS	Median	All	0.133	0.805	<.001	42	view →
UCEC	OS	Median	All	1.000	0.660	.023	24	view →
BLCA	DFS	Median	III,IV	0.121	0.548	.005	12	view →
LGG	DFS	Median	All	0.190	0.753	.002	6	view →
SCLC	DFS	Median	II,III,IV	0.137	0.562	.013	6	view →
SARC	DFS	Median	All	0.101	0.632	.011	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

GPR135–THCA (OS)

Open the THCA breakdown →