GPR12

Across TCGA patient cohorts, GPR12 mutation is significantly associated with the RNA expression of many other genes, with 1,674 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR12-associated genes across cancer lineages are HSPE1P12, SF3B5, and RNU6-1260P. Each is linked with GPR12 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR12-to-partner and partner-to-GPR12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSPE1P12 grouped by GPR12-low versus GPR12-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR12→partner) and Y-score (partner→GPR12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	HSPE1P12 →	+0.174	+5.257	<.001	.002	3	2
SKCM	SF3B5 →	+0.471	+3.198	.003	.009	3	2
SKCM	RNU6-1260P →	+0.192	+2.775	.001	.004	3	2
SKCM	ARRDC1-AS1 →	+0.575	+3.220	<.001	.009	3	2
SKCM	RNU6-213P →	+0.348	+2.487	<.001	.001	3	2
SKCM	RNU6-48P →	+0.544	+3.164	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,674 associations by consensus.

HSPE1P12 by GPR12 expression — READ

Explore this box plot interactively →