GPR12

Across TCGA cell cohorts, GPR12 RNA expression is significantly associated with the go_rna of many other GO terms, with 465 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible GPR12-associated GO terms across cancer lineages are Positive regulation of ossification, Immune response-activating cell surface receptor signaling pathway, and Epithelial cell migration. Each is linked with GPR12 in more than 2 cancer types. Because this analysis shows association rather than direction, both GPR12-to-partner and partner-to-GPR12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of ossification grouped by GPR12-low versus GPR12-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR12→partner) and Y-score (partner→GPR12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Positive regulation of ossification →	-0.057	-0.055	<.001	.006	3	3
LUNG_SCLC	Immune response-activating cell surface receptor signaling pathway →	-0.046	-1.722	.001	.001	3	3
LUNG_SCLC	Epithelial cell migration →	-0.108	-1.873	<.001	<.001	3	2
LUNG_SCLC	DNA replication-dependent chromatin disassembly →	+0.111	+1.588	.003	.005	3	2
LUNG_SCLC	Cell surface toll-like receptor signaling pathway →	-0.057	-1.481	<.001	.001	3	2
LUNG_SCLC	Negative regulation of transcription by RNA polymerase I →	+0.111	+1.797	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 465 associations by consensus.

Positive regulation of ossification by GPR12 expression — SKIN

Explore this box plot interactively →