GPR12

Across TCGA cell cohorts, GPR12 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GPR12-associated genes across cancer lineages are DPT, ZIC3, and PRICKLE2. Each is linked with GPR12 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR12-to-partner and partner-to-GPR12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DPT grouped by GPR12-low versus GPR12-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR12→partner) and Y-score (partner→GPR12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DPT →	+1.256	+4.091	<.001	.002	3	1
BLOOD_Leukemia	ZIC3 →	+0.012	+3.475	<.001	.006	3	1
BLOOD_Leukemia	PRICKLE2 →	+0.755	+3.594	<.001	.007	3	1
BLOOD_Leukemia	WFDC12 →	+0.163	+3.289	<.001	.009	3	1
BLOOD_Leukemia	OR13J1 →	+0.146	+4.096	<.001	.001	3	1
BLOOD_Leukemia	DEFB4A →	+0.078	+3.684	.005	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

DPT by GPR12 expression — BLOOD_Leukemia

Explore this box plot interactively →