GPR101

Across TCGA pan-cancer cohorts, GPR101 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated GPR101 data layer compared with 16 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher GPR101 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated GPR101 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUSC, LAML, and UCEC are the cancer types where GPR101 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	All	0.221	0.666	<.001	24	view →
LAML	DFS	Median	All	0.028	0.572	<.001	12	view →
UCEC	DFS	Median	II,III,IV	0.921	0.437	.025	8	view →
GBM	OS	Median	All	0.089	0.413	.015	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
BRCA	OS	Median	III,IV	0.667	0.905	.041	6	view →
SKCM	DFS	Median	III,IV	0.063	0.648	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

GPR101–LUSC (DFS)

Open the LUSC breakdown →