GPN3

Across TCGA pan-cancer cohorts, GPN3 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of GPN3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GPN3 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types GPN3 is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.

HNSC, LUAD, and COAD are the cancer types where GPN3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPN3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	−0.293	.004	8	view →
LUAD	All	All	−0.116	<.001	6	view →
COAD	All	All	−0.783	.025	4	view →
LSCC	All	All	−0.077	.009	4	view →
CCRCC	All	All	+0.111	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

GPN3–HNSC

Open the HNSC breakdown →