GPN2

Across TCGA cell cohorts, GPN2 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GPN2-associated genes across cancer lineages are PNLIP, OR4F15, and LRRC55. Each is linked with GPN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPN2-to-partner and partner-to-GPN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PNLIP grouped by GPN2-low versus GPN2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPN2→partner) and Y-score (partner→GPN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PNLIP →	+0.015	+5.539	.003	.003	3	1
BLOOD_Leukemia	OR4F15 →	+0.006	+5.201	<.001	.006	3	1
BLOOD_Leukemia	LRRC55 →	+0.006	+4.922	<.001	.009	3	1
BLOOD_Leukemia	PLCXD3 →	+0.033	+5.149	<.001	.006	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

PNLIP by GPN2 expression — BLOOD_Leukemia

Explore this box plot interactively →