Across TCGA pan-cancer cohorts, GPN1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GPN1 data layer compared with 27 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher GPN1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GPN1 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

UCEC, LSCC, and LUAD are the cancer types where GPN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.550	0.857	.033	4	view →
LSCC	DFS	Quartile	All	1.000	0.892	.020	4	view →
LUAD	OS	Quartile	II,III,IV	0.266	0.836	.049	2	view →
HNSC	DFS	Median	III,IV	0.937	1.000	.035	1	view →
PDAC	DFS	Median	III,IV	0.504	0.825	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: GPN1 tumor-vs-normal RNA expression · all GPN1 data types