Across TCGA patient cohorts, GPN1 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPN1-associated genes across cancer lineages are EGFR_pY1068, FOXO3a, and IGFBP2. Each is linked with GPN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPN1-to-partner and partner-to-GPN1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPN1→partner) and Y-score (partner→GPN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.277	-1.874	.007	.049	3	1
UCEC	FOXO3a →	+0.100	+1.820	.016	.016	3	1
UCEC	IGFBP2 →	-0.929	-3.321	<.001	.009	3	1
UCEC	INPP4B →	-0.299	-1.794	.025	.027	3	1
UCEC	JNK2 →	+0.352	+3.000	<.001	.001	3	1
UCEC	MEK1 →	+0.443	+2.584	.003	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

GPN1 survival (RNA) · tumor vs normal (RNA) · all GPN1 data types