GPLD1

Across TCGA patient cohorts, GPLD1 mutation is significantly associated with the RNA expression of many other genes, with 3,207 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPLD1-associated genes across cancer lineages are HTRA2, MSANTD3, and RAD23A. Each is linked with GPLD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GPLD1-to-partner and partner-to-GPLD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HTRA2 grouped by GPLD1-low versus GPLD1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPLD1→partner) and Y-score (partner→GPLD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	HTRA2 →	+0.272	+3.547	.005	.002	3	3
UCEC	MSANTD3 →	+0.569	+2.679	<.001	<.001	3	3
COAD	RAD23A →	+0.322	+2.834	.008	.001	3	3
UCEC	TMEM138 →	+0.238	+2.595	.002	<.001	3	3
UCEC	TATDN2 →	+0.263	+1.895	.005	.001	3	3
UCEC	VDAC2 →	+0.405	+2.169	.007	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,207 associations by consensus.

HTRA2 by GPLD1 expression — SKCM

Explore this box plot interactively →