GPLD1

Across TCGA patient cohorts, GPLD1 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPLD1-associated genes across cancer lineages are 4E-BP1, Cyclin-B1, and AMPK_alpha. Each is linked with GPLD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPLD1-to-partner and partner-to-GPLD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by GPLD1-low versus GPLD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPLD1→partner) and Y-score (partner→GPLD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.237	+2.252	.015	.005	3	2
UCEC	Cyclin-B1 →	+0.438	+2.000	.030	.030	3	2
SKCM	AMPK_alpha →	+0.112	+2.321	.040	.032	3	1
UCEC	eEF2 →	+0.277	+2.321	.031	.033	3	1
UCEC	EGFR_pY1068 →	-0.205	-1.584	.023	.019	3	1
UCEC	A-Raf_pS299 →	-0.109	-2.222	.011	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

4E-BP1 by GPLD1 expression — UCEC

Explore this box plot interactively →