GPLD1

Across TCGA cell cohorts, GPLD1 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible GPLD1-associated genes across cancer lineages are C12orf40, SLC35G3, and TMEM235. Each is linked with GPLD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GPLD1-to-partner and partner-to-GPLD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C12orf40 grouped by GPLD1-low versus GPLD1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPLD1→partner) and Y-score (partner→GPLD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	C12orf40 →	+0.007	+2.859	.003	.008	3	3
URINARY_TRACT	SLC35G3 →	+0.006	+5.087	<.001	.004	3	1
URINARY_TRACT	TMEM235 →	+0.020	+5.087	<.001	.004	3	1
LUNG_SCLC	SERPINA11 →	+1.620	+4.044	<.001	.009	3	1
LUNG_SCLC	OR52K1 →	+0.005	+4.643	<.001	.004	3	1
LUNG_SCLC	OR6V1 →	+0.024	+4.817	.007	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

C12orf40 by GPLD1 expression — OVARY

Explore this box plot interactively →