GPKOW

Across TCGA patient cohorts, GPKOW mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPKOW-associated genes across cancer lineages are eEF2, eIF4E, and ERK2. Each is linked with GPKOW in more than 1 cancer types. Because this analysis shows association rather than direction, both GPKOW-to-partner and partner-to-GPKOW results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by GPKOW-low versus GPKOW-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPKOW→partner) and Y-score (partner→GPKOW) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.280	+2.321	.021	.033	3	1
UCEC	eIF4E →	+0.168	+1.514	.019	.015	3	1
UCEC	ERK2 →	+0.189	+2.906	.004	.001	3	1
UCEC	MEK1 →	+0.378	+2.502	.002	.001	3	1
UCEC	MSH2 →	-0.200	-1.973	.010	.029	3	1
UCEC	mTOR_pS2448 →	-0.101	-1.980	.047	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

eEF2 by GPKOW expression — UCEC

Explore this box plot interactively →