GPKOW

Across TCGA cell cohorts, GPKOW RNA expression is significantly associated with the go_rna of many other GO terms, with 3,064 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible GPKOW-associated GO terms across cancer lineages are Growth hormone secretion, Type 2 mitophagy, and Regulation of autophagosome maturation. Each is linked with GPKOW in more than 15 cancer types. Because this analysis shows association rather than direction, both GPKOW-to-partner and partner-to-GPKOW results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Growth hormone secretion grouped by GPKOW-low versus GPKOW-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GPKOW→partner) and Y-score (partner→GPKOW) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Growth hormone secretion →	+0.144	+0.984	.003	<.001	3	16
LIVER	Type 2 mitophagy →	+0.200	+0.780	<.001	<.001	3	13
LARGE_INTESTINE	Regulation of autophagosome maturation →	+0.095	+0.624	<.001	<.001	3	12
BREAST	Regulation of heterochromatin formation →	+0.090	+1.147	.003	<.001	3	12
LARGE_INTESTINE	Regulation of protein sumoylation →	+0.093	+0.462	.003	.004	3	11
UPPER_AERODIGESTIVE_TRACT	Regulation of heterochromatin organization →	+0.080	+0.617	.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,064 associations by consensus.

Growth hormone secretion by GPKOW expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →