GPHB5

Across TCGA patient cohorts, GPHB5 mutation is significantly associated with the RNA expression of many other genes, with 388 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPHB5-associated genes across cancer lineages are NPLP1, RNU6-218P, and UBTFL7. Each is linked with GPHB5 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPHB5-to-partner and partner-to-GPHB5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPLP1 grouped by GPHB5-low versus GPHB5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPHB5→partner) and Y-score (partner→GPHB5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	NPLP1 →	+0.214	+5.080	<.001	.008	3	2
SKCM	RNU6-218P →	+0.364	+2.785	.005	.003	3	2
SKCM	UBTFL7 →	+0.036	+3.232	<.001	.002	3	2
COAD	RNA5SP41 →	+0.697	+6.122	<.001	.002	3	1
COAD	LINC01708 →	+0.175	+6.003	<.001	.002	3	1
COAD	SEPTIN7P4 →	+0.247	+6.917	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 388 associations by consensus.

NPLP1 by GPHB5 expression — COAD

Explore this box plot interactively →