GPER1

Across TCGA patient cohorts, GPER1 mutation is significantly associated with the RNA expression of many other genes, with 3,253 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPER1-associated genes across cancer lineages are COX15, OXSM, and CENPU. Each is linked with GPER1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPER1-to-partner and partner-to-GPER1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX15 grouped by GPER1-low versus GPER1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPER1→partner) and Y-score (partner→GPER1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	COX15 →	+0.514	+3.472	<.001	.002	3	2
UCEC	OXSM →	+0.262	+2.700	.008	.005	3	2
UCEC	CENPU →	+0.660	+2.233	<.001	<.001	3	2
UCEC	SLC25A4 →	+0.488	+2.233	<.001	.005	3	2
UCEC	AP1S3 →	+0.764	+3.169	<.001	<.001	3	2
UCEC	SPC25 →	+0.589	+2.233	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,253 associations by consensus.

COX15 by GPER1 expression — COAD

Explore this box plot interactively →