GPER1

Across TCGA patient cohorts, GPER1 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPER1-associated genes across cancer lineages are ASNS, eEF2, and ERK2. Each is linked with GPER1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GPER1-to-partner and partner-to-GPER1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by GPER1-low versus GPER1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPER1→partner) and Y-score (partner→GPER1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.515	+1.700	<.001	.042	3	3
UCEC	eEF2 →	+0.418	+2.115	.002	.017	3	2
UCEC	ERK2 →	+0.203	+3.584	.007	.002	3	2
UCEC	MEK1 →	+0.436	+4.000	.002	<.001	3	2
UCEC	EGFR_pY1068 →	-0.209	-2.000	.033	.010	3	1
UCEC	eIF4E →	+0.270	+3.169	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

ASNS by GPER1 expression — UCEC

Explore this box plot interactively →