GPER1

Across TCGA cell cohorts, GPER1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,011 significant associations in total. BONE shows the largest number of these associations.

The most reproducible GPER1-associated GO terms across cancer lineages are Apoptotic chromosome condensation, Cellular senescence, and Positive regulation of amyloid-beta clearance. Each is linked with GPER1 in more than 14 cancer types. Because this analysis shows association rather than direction, both GPER1-to-partner and partner-to-GPER1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Apoptotic chromosome condensation grouped by GPER1-low versus GPER1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GPER1→partner) and Y-score (partner→GPER1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Apoptotic chromosome condensation →	-0.181	-1.065	.007	.004	3	15
LARGE_INTESTINE	Cellular senescence →	+0.075	+0.892	<.001	.005	3	7
LIVER	Positive regulation of amyloid-beta clearance →	+0.295	+2.144	<.001	.003	3	7
BONE	Intracellular receptor signaling pathway →	+0.031	+0.798	.005	.001	3	6
BREAST	Viral genome replication →	+0.161	+1.124	.001	.001	3	6
UPPER_AERODIGESTIVE_TRACT	Regulation of DNA-templated transcription elongation →	+0.057	+0.698	.004	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,011 associations by consensus.

Apoptotic chromosome condensation by GPER1 expression — BONE

Explore this box plot interactively →