GPD2

Across TCGA patient cohorts, GPD2 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPD2-associated genes across cancer lineages are ERK2, 14-3-3_beta, and EGFR_pY1068. Each is linked with GPD2 in more than 2 cancer types. Because this analysis shows association rather than direction, both GPD2-to-partner and partner-to-GPD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by GPD2-low versus GPD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPD2→partner) and Y-score (partner→GPD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.199	+1.459	.001	.012	3	3
UCEC	14-3-3_beta →	-0.106	-2.388	.001	.002	3	2
UCEC	EGFR_pY1068 →	-0.340	-2.700	<.001	<.001	3	2
UCEC	FoxM1 →	+0.206	+1.716	.014	.003	3	2
UCEC	INPP4B →	-0.304	-2.906	.003	.001	3	2
UCEC	MEK1 →	+0.402	+2.000	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

ERK2 by GPD2 expression — UCEC

Explore this box plot interactively →