GPD2

Across TCGA cell cohorts, GPD2 mutation is significantly associated with the RNA expression of many other genes, with 503 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GPD2-associated genes across cancer lineages are CSN1S1, GCAT, and JOSD1. Each is linked with GPD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPD2-to-partner and partner-to-GPD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CSN1S1 grouped by GPD2-low versus GPD2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPD2→partner) and Y-score (partner→GPD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CSN1S1 →	+0.028	+4.887	<.001	.009	3	1
LARGE_INTESTINE	GCAT →	+1.365	+3.321	<.001	.003	3	1
LARGE_INTESTINE	JOSD1 →	+0.495	+2.502	.007	.005	3	1
LARGE_INTESTINE	FBXO7 →	+0.381	+2.502	.002	.005	3	1
LARGE_INTESTINE	ST13 →	+0.496	+3.321	.003	.003	3	1
LARGE_INTESTINE	L3MBTL2 →	+0.624	+3.459	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 503 associations by consensus.

CSN1S1 by GPD2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →