GPD1

Across TCGA patient cohorts, GPD1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPD1-associated genes across cancer lineages are eEF2, EGFR_pY1068, and eIF4E. Each is linked with GPD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPD1-to-partner and partner-to-GPD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by GPD1-low versus GPD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPD1→partner) and Y-score (partner→GPD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.289	+1.906	.045	.016	3	1
UCEC	EGFR_pY1068 →	-0.276	-2.222	.006	.010	3	1
UCEC	eIF4E →	+0.172	+1.906	.043	.016	3	1
UCEC	A-Raf_pS299 →	-0.132	-2.321	.006	.034	3	1
UCEC	ERK2 →	+0.224	+2.115	.003	.017	3	1
UCEC	JNK2 →	+0.209	+2.469	.009	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

eEF2 by GPD1 expression — UCEC

Explore this box plot interactively →