GPD1

Across TCGA cell cohorts, GPD1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,376 significant associations in total. BONE shows the largest number of these associations.

The most reproducible GPD1-associated GO terms across cancer lineages are Positive regulation of sphingolipid biosynthetic process, Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I, and Establishment of protein localization to organelle. Each is linked with GPD1 in more than 7 cancer types. Because this analysis shows association rather than direction, both GPD1-to-partner and partner-to-GPD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of sphingolipid biosynthetic process grouped by GPD1-low versus GPD1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GPD1→partner) and Y-score (partner→GPD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Positive regulation of sphingolipid biosynthetic process →	+0.124	+0.567	.008	.009	3	8
OVARY	Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.109	+0.446	.005	<.001	3	8
OVARY	Establishment of protein localization to organelle →	+0.041	+0.352	<.001	.002	3	8
KIDNEY	Negative regulation of spindle checkpoint →	-0.196	-1.071	<.001	<.001	3	8
KIDNEY	Fatty acid catabolic process →	+0.061	+0.772	.007	.004	3	8
LUNG_NSCLC_LUSC	Positive regulation of ceramide biosynthetic process →	+0.124	+0.567	.008	.009	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,376 associations by consensus.

Positive regulation of sphingolipid biosynthetic process by GPD1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →