GPCPD1

Across TCGA patient cohorts, GPCPD1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPCPD1-associated genes across cancer lineages are EGFR_pY1068, FoxM1, and GSK-3_pS9. Each is linked with GPCPD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPCPD1-to-partner and partner-to-GPCPD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by GPCPD1-low versus GPCPD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPCPD1→partner) and Y-score (partner→GPCPD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.305	-2.169	.001	.003	3	1
UCEC	FoxM1 →	+0.219	+2.662	.024	<.001	3	1
UCEC	GSK-3_pS9 →	-0.385	-2.000	.011	.029	3	1
UCEC	INPP4B →	-0.332	-3.700	.006	.001	3	1
UCEC	JNK_pT183_Y185 →	-0.179	-2.807	.004	.003	3	1
UCEC	JNK2 →	+0.212	+2.169	.004	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

EGFR_pY1068 by GPCPD1 expression — UCEC

Explore this box plot interactively →