Across TCGA patient cohorts, GPC6 RNA expression is significantly associated with the protein abundance of many other proteins, with 21,138 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GPC6-associated proteins across cancer lineages are MMP2, P4HA1, and SEC23A. Each is linked with GPC6 in more than 7 cancer types. Because this analysis shows association rather than direction, both GPC6-to-partner and partner-to-GPC6 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GPC6→partner) and Y-score (partner→GPC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MMP2 →	+0.704	+0.858	<.001	<.001	3	8
LUAD	P4HA1 →	+0.781	+1.216	<.001	<.001	3	8
OV	SEC23A →	+0.338	+1.073	<.001	<.001	3	8
LSCC	LOXL2 →	+0.803	+1.007	<.001	<.001	3	8
OV	ANTXR1 →	+0.619	+1.520	<.001	<.001	3	8
LUAD	THY1 →	+0.660	+1.295	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,138 associations by consensus.

Exploration

GPC6 survival (RNA) · tumor vs normal (RNA) · all GPC6 data types