GPC6

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, GPC6 protein abundance is significantly associated with the RNA expression of many other genes, with 14,763 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GPC6-associated genes across cancer lineages are OLFML2B, CRISPLD2, and PCOLCE. Each is linked with GPC6 in more than 8 cancer types. Because this analysis shows association rather than direction, both GPC6-to-partner and partner-to-GPC6 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPC6→partner) and Y-score (partner→GPC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVOLFML2B →+1.016+0.424<.001<.00139
OVCRISPLD2 →+1.431+0.527<.001<.00139
OVPCOLCE →+1.418+0.724<.001<.00139
HNSCRGS4 →+0.979+0.477.001.00139
OVGLT8D2 →+1.273+0.568<.001<.00139
LSCCTSHZ3 →+0.711+0.626<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 14,763 associations by consensus.

Exploration