Across TCGA patient cohorts, GPC6 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPC6-associated genes across cancer lineages are Caspase-7-cleavedD198, 4E-BP1, and Cyclin-B1. Each is linked with GPC6 in more than 2 cancer types. Because this analysis shows association rather than direction, both GPC6-to-partner and partner-to-GPC6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPC6→partner) and Y-score (partner→GPC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.794	+2.189	<.001	.001	3	3
SKCM	4E-BP1 →	+0.277	+1.906	.022	.016	3	3
UCEC	Cyclin-B1 →	+0.633	+2.321	<.001	<.001	3	3
LUAD	FoxM1 →	+0.328	+3.033	.010	.017	3	2
UCEC	eIF4E →	+0.170	+3.472	.013	.002	3	2
UCEC	FOXO3a_pS318_S321 →	-0.097	-1.492	.016	.027	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Exploration

GPC6 survival (RNA) · tumor vs normal (RNA) · all GPC6 data types