Across TCGA patient cohorts, GPC2 mutation is significantly associated with the RNA expression of many other genes, with 2,651 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPC2-associated genes across cancer lineages are RNA5SP405, MIR509-1, and CICP21. Each is linked with GPC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both GPC2-to-partner and partner-to-GPC2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPC2→partner) and Y-score (partner→GPC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP405 →	+0.250	+3.122	<.001	.001	3	3
HNSC	MIR509-1 →	+0.338	+7.954	<.001	.008	3	2
SKCM	CICP21 →	+0.056	+3.086	<.001	.007	3	2
CESC	RNA5SP92 →	+0.325	+4.816	.001	.003	3	2
CESC	FAM30C →	+0.066	+5.569	<.001	.002	3	2
LUAD	LINC01047 →	+0.290	+4.683	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,651 associations by consensus.

Exploration

GPC2 survival (RNA) · tumor vs normal (RNA) · all GPC2 data types