Across TCGA patient cohorts, GPC2 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPC2-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and INPP4B. Each is linked with GPC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPC2-to-partner and partner-to-GPC2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPC2→partner) and Y-score (partner→GPC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.646	+2.135	.006	.010	3	2
UCEC	EGFR_pY1068 →	-0.239	-1.906	.018	.016	3	1
UCEC	INPP4B →	-0.310	-2.584	.017	.010	3	1
UCEC	Ku80 →	+0.195	+2.594	.040	.006	3	1
UCEC	MEK1 →	+0.393	+2.115	.007	.017	3	1
UCEC	PDCD4 →	-0.414	-1.906	.029	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration

GPC2 survival (RNA) · tumor vs normal (RNA) · all GPC2 data types