GPC1

Across TCGA pan-cancer cohorts, GPC1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GPC1 data layer compared with 31 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher GPC1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated GPC1 expression acts as an unfavorable survival marker.

CCRCC, UCEC, and PDAC are the cancer types where GPC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	III,IV	0.667	1.000	.003	44	view →
UCEC	DFS	Tertile	All	0.751	0.952	.016	12	view →
PDAC	DFS	Quartile	III,IV	0.227	0.904	.006	9	view →
GBM	OS	Median	All	0.775	0.928	.009	2	view →
LSCC	DFS	Median	All	0.905	1.000	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GPC1–CCRCC (OS)

Open the CCRCC breakdown →