GPC1

Across TCGA cell cohorts, GPC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,831 significant associations in total. BONE shows the largest number of these associations.

The most reproducible GPC1-associated GO terms across cancer lineages are Positive regulation of plasma membrane repair, Regulation of fibroblast proliferation, and Positive regulation of protein localization to membrane. Each is linked with GPC1 in more than 14 cancer types. Because this analysis shows association rather than direction, both GPC1-to-partner and partner-to-GPC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of plasma membrane repair grouped by GPC1-low versus GPC1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GPC1→partner) and Y-score (partner→GPC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of plasma membrane repair →	+0.344	+2.842	<.001	<.001	3	15
OESOPHAGUS	Regulation of fibroblast proliferation →	+0.113	+1.861	.009	.001	3	15
BONE	Positive regulation of protein localization to membrane →	+0.086	+2.326	.001	.003	3	14
BONE	Gliogenesis →	+0.087	+2.645	<.001	<.001	3	14
LUNG_NSCLC_LUAD	Negative regulation of transforming growth factor beta production →	+0.213	+1.356	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Chaperone-mediated autophagy →	+0.141	+1.580	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,831 associations by consensus.

Positive regulation of plasma membrane repair by GPC1 expression — BONE

Explore this box plot interactively →