GPC1

Across TCGA cell cohorts, GPC1 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GPC1-associated genes across cancer lineages are DOK5, MARK1, and ABCA12. Each is linked with GPC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPC1-to-partner and partner-to-GPC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DOK5 grouped by GPC1-low versus GPC1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPC1→partner) and Y-score (partner→GPC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DOK5 →	+0.062	+3.882	.009	<.001	3	1
BLOOD_Leukemia	MARK1 →	+0.589	+3.835	.009	.001	3	1
BLOOD_Leukemia	ABCA12 →	+0.536	+3.237	.003	.001	3	1
BLOOD_Leukemia	FCRL3 →	+0.651	+2.453	<.001	.009	2	2
BLOOD_Leukemia	OR4F6 →	+0.011	+2.922	<.001	.009	3	1
BLOOD_Leukemia	DEFB108B →	+0.078	+3.362	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

DOK5 by GPC1 expression — BLOOD_Leukemia

Explore this box plot interactively →