GPBP1L1

Across TCGA patient cohorts, GPBP1L1 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPBP1L1-associated genes across cancer lineages are JNK_pT183_Y185, Ku80, and Rab25. Each is linked with GPBP1L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPBP1L1-to-partner and partner-to-GPBP1L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by GPBP1L1-low versus GPBP1L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPBP1L1→partner) and Y-score (partner→GPBP1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.190	-2.489	.004	.002	3	2
UCEC	Ku80 →	+0.199	+2.013	.032	.005	3	2
UCEC	Rab25 →	-0.464	-3.321	<.001	.009	3	2
UCEC	Chk2_pT68 →	-0.162	-3.295	.027	.009	3	2
UCEC	14-3-3_beta →	-0.102	-2.295	.009	.033	3	1
UCEC	eEF2 →	+0.460	+2.584	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

JNK_pT183_Y185 by GPBP1L1 expression — UCEC

Explore this box plot interactively →