GPBP1

Across TCGA pan-cancer cohorts, GPBP1 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of GPBP1’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where GPBP1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types GPBP1 is over-expressed in tumor, although a few such as HNSC and PDAC show the opposite, repressed pattern.

CCRCC, HNSC, and PDAC are the cancer types where GPBP1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPBP1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	All	All	+0.416	<.001	11	view →
HNSC	Male	All	−0.479	<.001	7	view →
PDAC	All	II,III,IV	−0.216	.030	2	view →
LSCC	Male	All	−0.089	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

GPBP1–CCRCC

Open the CCRCC breakdown →