Across TCGA pan-cancer cohorts, GPATCH8 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of GPATCH8’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GPATCH8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GPATCH8 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.
HNSC, COAD, and KIRP are the cancer types where GPATCH8 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GPATCH8 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.