GPATCH4

Across TCGA patient cohorts, GPATCH4 mutation is significantly associated with the RNA expression of many other genes, with 651 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPATCH4-associated genes across cancer lineages are MIR4769, OR11H3P, and MIR4287. Each is linked with GPATCH4 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPATCH4-to-partner and partner-to-GPATCH4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4769 grouped by GPATCH4-low versus GPATCH4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPATCH4→partner) and Y-score (partner→GPATCH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR4769 →	+0.343	+3.442	<.001	.004	3	2
BRCA	OR11H3P →	+0.069	+9.057	<.001	.003	3	1
UCEC	MIR4287 →	+0.221	+3.923	<.001	.009	3	1
UCEC	SNRPCP20 →	+0.265	+3.048	<.001	<.001	3	1
UCEC	SNHG30 →	+0.576	+3.330	.005	.005	3	1
UCEC	CIRBP-AS1 →	+0.683	+3.393	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 651 associations by consensus.

MIR4769 by GPATCH4 expression — UCEC

Explore this box plot interactively →