GPATCH4

Across TCGA patient cohorts, GPATCH4 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPATCH4-associated genes across cancer lineages are JNK2, STAT3_pY705, and Syk. Each is linked with GPATCH4 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPATCH4-to-partner and partner-to-GPATCH4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by GPATCH4-low versus GPATCH4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPATCH4→partner) and Y-score (partner→GPATCH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.404	+3.179	<.001	.010	3	1
UCEC	STAT3_pY705 →	-0.480	-3.159	<.001	.019	3	1
UCEC	Syk →	+0.440	+2.183	.025	.035	3	1
UCEC	beta-Catenin →	+0.550	+3.321	.038	.010	3	1
UCEC	Notch1 →	+0.217	+3.009	.003	.019	2	1
UCEC	SLC1A5 →	-0.548	-3.314	.013	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

JNK2 by GPATCH4 expression — UCEC

Explore this box plot interactively →