Across TCGA patient cohorts, GPATCH3 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPATCH3-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and JNK2. Each is linked with GPATCH3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPATCH3-to-partner and partner-to-GPATCH3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPATCH3→partner) and Y-score (partner→GPATCH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.291	-2.906	.006	.001	3	1
UCEC	eIF4E →	+0.238	+4.000	.007	<.001	3	1
UCEC	JNK2 →	+0.228	+3.026	.006	.018	3	1
UCEC	PCNA →	+0.216	+2.222	.018	.011	3	1
UCEC	Annexin-1 →	+0.652	+3.189	.003	.010	3	1
UCEC	Tuberin →	+0.309	+1.884	.006	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

GPATCH3 survival (RNA) · tumor vs normal (RNA) · all GPATCH3 data types