GPATCH2

Across TCGA cell cohorts, GPATCH2 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible GPATCH2-associated genes across cancer lineages are OR1N2, OR52K1, and KRTAP19-3. Each is linked with GPATCH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPATCH2-to-partner and partner-to-GPATCH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1N2 grouped by GPATCH2-low versus GPATCH2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPATCH2→partner) and Y-score (partner→GPATCH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR1N2 →	+0.025	+5.029	<.001	.006	3	1
LUNG_SCLC	OR52K1 →	+0.006	+5.643	<.001	.002	3	1
LUNG_SCLC	KRTAP19-3 →	+0.241	+5.029	<.001	.006	3	1
SKIN	IL17F →	+0.036	+5.217	<.001	<.001	3	1
BREAST	CCDC105 →	+0.006	+5.169	<.001	.005	3	1
BREAST	OR2M3 →	+0.006	+5.169	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

OR1N2 by GPATCH2 expression — LUNG_SCLC

Explore this box plot interactively →