GPATCH1

Across TCGA patient cohorts, GPATCH1 mutation is significantly associated with the RNA expression of many other genes, with 4,896 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPATCH1-associated genes across cancer lineages are CYCSP35, RETSAT, and FANCE. Each is linked with GPATCH1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GPATCH1-to-partner and partner-to-GPATCH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYCSP35 grouped by GPATCH1-low versus GPATCH1-high in GBM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPATCH1→partner) and Y-score (partner→GPATCH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CYCSP35 →	+0.272	+5.352	<.001	.005	3	3
UCEC	RETSAT →	+0.513	+2.330	<.001	<.001	3	3
UCEC	FANCE →	+0.462	+3.606	.003	.001	3	3
LUSC	GIMAP1-GIMAP5 →	+0.017	+4.623	<.001	.001	3	2
BRCA	ZDHHC20P2 →	+0.069	+4.317	.004	.001	3	2
UCEC	ABALON →	+0.470	+1.555	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,896 associations by consensus.

CYCSP35 by GPATCH1 expression — GBM

Explore this box plot interactively →