GPATCH1

Across TCGA patient cohorts, GPATCH1 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPATCH1-associated genes across cancer lineages are ATM, Notch1, and PCNA. Each is linked with GPATCH1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GPATCH1-to-partner and partner-to-GPATCH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by GPATCH1-low versus GPATCH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPATCH1→partner) and Y-score (partner→GPATCH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.607	-2.321	<.001	.001	3	3
UCEC	Notch1 →	+0.146	+2.128	.003	.009	3	2
UCEC	PCNA →	+0.210	+1.925	.006	.005	3	2
UCEC	Tuberin →	+0.374	+2.807	<.001	.002	3	2
UCEC	CD49b →	-0.308	-3.446	.002	.005	3	2
UCEC	14-3-3_beta →	-0.107	-3.673	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

ATM by GPATCH1 expression — UCEC

Explore this box plot interactively →